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INTRODUCTION

Pathology MOC Activity ID

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 0.50

Target Audience:

Pathologists, Pathology Residents, Medical Students, Pathology Assistants and Pathology Assistant Students.

Educational Objectives:

Upon completion of this activity, participants will be able to:

  • Increase awareness of tumor types induced by viruses in immunosuppressed patients.
  • Be aware of techniques used to detect virus in tumor cells.
  • Develop a differential diagnosis of spindled cell lesions in immunocompromised hosts.
SPECIAL NOTE:
There is no educational content to this course. This course is designed to supplement training that has already occurred. This course is designed to only administer the required post-test and collect CME evaluations.

This course is eligible for The American Board of Pathology SAM credit.

Suggested Additional Reading:

  1. Chadwick, E. G. (1990). Tumors of Smooth-Muscle Origin in HIV-Infected Children. JAMA, 263(23), 3182. http://doi.org/10.1001/jama.1990.03440230078037.
  2. Dekate, J., & Chetty, R. (2016). Epstein-Barr virus-associated smooth muscle tumor. Arch Path Lab Med, 140(7), 718-722. http://doi.org/10.5858/arpa.2015-0120-RS)
  3. Deyrup, AT, Lee, VK, Hill, CE, et. al. (2006). Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Path, 30(1), 75-82. http://doi.org/10.1097/01.pas.0000178088.69394.7b
  4. Hussein, K., Rath, B., Ludewig, B., et. al. (2014). Clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours. Eur J Cancer (Oxford, England: 1990), 50(14), 2417-2424. http://doi.org/10.1016/j.ejca.2014.06.006 [doi]
  5. Jonigk, D., Izykowski, N., Maegel, L., et. al. (2013). MicroRNA expression in Epstein-Barr virus-associated post-transplant smooth muscle tumours is related to leiomyomatous phenotype. Clin Sarcoma Res, 3(1), 9. http://doi.org/10.1186/2045-3329-3-9
  6. Lee, E. S., Locker, J., Nalesnik, M., et. al. (1995). The Association of Epstein-Barr Virus with Smooth-Muscle Tumors Occurring after Organ Transplantation. N Eng J Med, 332(1), 19-25. http://doi.org/10.1056/NEJM199501053320104
  7. McClain, KL, Leach, CT, Jenson, HB, et. al.(1995). Association of Epstein-Barr Virus with Leiomyosarcomas in Young People with AIDS. N Eng J Med, 332(1), 12-18. http://doi.org/10.1056/NEJM199501053320103
  8. Pritzker, KP, Huang, SN, & Marshall, KG (1970). Malignant tumours following immunosuppressive therapy. Can Med Assoc J, 103(13), 1362-5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/4923839\n http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC1930644

Authors:
Michael A. Nalesnik, MD — Professor of Pathology, Division of Transplantation Pathology, Department of Pathology, University of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
Mohamed El Hag, MD — Clinical Fellow, Transplant Pathology, University of Pittsburgh, Department of Pathology
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.