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10/4/2016 - Medical Grand Rounds: The Bench to Bedside: Future of Pharmacogenomics and Precision Therapeutics





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe why pharmacogenomics is a leading use case for precision medicine.
  • Integrate genetic data with clinical variables to guide antiplatelet medication prescribing following percutaneous coronary intervention.
  • Improved the ability to diagnose the etiology of heart failure in African Americans.
  • Improve outcomes by increased utilization of proven heart failure therapies.
  • Recognize the potential of genomics to target therapy in the future.

Suggested Additional Reading:

  1. Yancy CW. J Card Fail. 2000;6:183�186.
  2. Hare JM. N Engl J Med. 2004;351:2112-2114.
  3. Carson P, et al. J Card Fail. 1999;5178-187.
  4. Rosskopf et al. Hypertension 2000 (36) 33-41.
  5. McNamara DM, et al. JACC Heart Fail. 2014;2(6):551-557.
  6. Ware JS et al. N Engl J Med 2016;374:233-241.
  7. Meyer UA. Nat Rev Genet. 2004;5(9):669-676.
  8. Empey et al. Crit Care Med. 38(6):S106-16.
  9. Shuldiner et al. JAMA 2009;302(8):849-857.
  10. Scott et al. CP&T. 2011;90(2):328-32.
  11. Kim et al. CP&T. 2008;84(2):236-242.
  12. Mega et al. NEJM. 2009;360(4):354-362.
  13. Simon et al. NEJM. 2009; 360(4): 363-75.

Dennis McNamara, MD — Professor of Medicine, HVI Division of Cardiology Director, Center for Heart Failure Research Co-Director, Peripartum Cardiomyopathy Network
Dr. McNamara receives grant/research support from Arbor Pharmaceutical Co. by providing drug for GRAH2. He is a consultant for Sanofi Pharmaceutical, and GE Healthcare.
Philip E. Empey, PharmD, PhD — Assistant Professor, Pharmacy and Therapeutics Associate Director for Pharmacogenomics of the Pitt/UPMC Institute of Personalized Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Authors disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.