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INTRODUCTION

ABIM MOC Activity ID

1/10/2017 - Medical Grand Rounds: Sepsis Bench-to-Bedside

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe the basic mechanism of sepsis.
  • Assess potential future sepsis therapies.
  • Better manage the clinical aspects of sepsis

Presentation Topics
Title:  Making Inroads in Sepsis
Presenter:  Derek C. Angus, MD, MPH, FRCP

Title:  Sepsis: Bench-to-Bedside
Presenter:  Bill Chen, Ph.D.

Suggested Additional Reading:

  1. Chen BB, Coon TA, Glasser JR, McVerry BJ, Zhao J, Zhao Y, Zou C, Ellis BM, Sciurba FC, Zhang Y, *Mallampalli RK. A combinatorial F box protein directed pathway controls TRAF stability to regulate inflammation. Nat Immunol. 2013 Mar 31. doi: 10.1038/ni.2565. [Epub ahead of print]. PMCID: PMC3631463. Highlighted in Nat Rev Immunol and Nat Rev Drug Design.
  2. McKelvey AC, Lear T, Dunn SR, Evankovich J, Landino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, Chen BB. RING Finger E3 Ligase PPP1R11 Regulates TLR2 Signaling and Innate Immunity. eLife 2016 Nov 2;5. pii: e18496. doi: 10.7554/eLife.18496. PMID: 27805901, PMCID: PMC5092053.
  3. Hotchkiss RS and Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nature Reviews Immunology 6, 813-822. 2006 Nov doi:10.1038/nri1943.

Authors:
Bill Chen, PhD — Associate Professor of Medicine Director, Small Molecule Therapeutic Center Co-director, Acute Lung Injury Center of Excellence Division of Pulmonary, Allergy and Critical Care Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Derek C. Angus, MD, MPH, FRCP — Distinguished Professor and Mitchell P. Fink Endowed Chair Department of Critical Care Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.