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INTRODUCTION

ABIM MOC Activity ID

11/27/2018 - Medical Grand Rounds: Special K Klub - K-award winners: Evaluating National Sepsis Health Policy, Timing Mutagenesis in the Bacterial SOS DNA Repair Pathway, Cortical Control of the Stomach & Relevance to Alzheimer's Disease

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Improve patient outcomes by increasing adherence to best practices for patients with sepsis.
  • Increase knowledge of how antibiotic exposure can accelerate the acquisition of antibiotic resistance.
  • Identify cortical and sub-cortical brain structures that influence the parasympathetic control of organ function.

Presentation Topics
Title:  Evaluating National Sepsis Health Policy
Presenter:  Ian Barbash, MD

Title:  Timing Mutagenesis in the Bacterial SOS DNA Repair Pathway
Presenter:  Matthew Culyba, MD, PhD

Title:  Cortical Control of the Stomach and its Potential Relevance to Alzheimer's Disease
Presenter:  David Levinthal, MD, PhD

Suggested Additional Reading:

1) Dum RP, Levinthal DJ, Strick PL (2016) Motor, cognitive, and affective areas of the cerebral cortex influence the adrenal medulla. Proceedings of the National Academy of Sciences 113(35): 9922-9927.<br>

2) Craig AD (2009) How do you feel--now? The anterior insula and human awareness. Nat Rev Neurosci. 10(1):59-70.<br>

3) Gianaros PJ, Jennings JR. (2018) Host in the machine: A neurobiological perspective on psychological stress and cardiovascular disease. Am Psychol. 73(8):1031-1044. <br>

4) Culyba MJ, Mo CY, Kohli RM (2015). Targets for combating the evolution of acquired antibiotic resistance. Biochemistry. 54(23):3573-82. PMID: 26016604 <br>

5) Culyba MJ, Kubiak JM, Mo CY, Goulian M, Kohli RM (2018). Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network. PLoS Genet. 14(6): e1007405; PMID: 29856734<br>

6) Culyba MJ (2018). Ordering up gene expression by slowing down transcription factor binding kinetics. Curr Genet. doi: 10.1007/s00294-018-0896-7; PMID: 30353359

Authors:
David Levinthal, MD, PhD — Division of Gastroenterology, Hepatology and Nutrition Assistant Professor of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Ian Barbash, MD — Division of Pulmonary, Allergy and Critical Care Medicine Assistant Professor of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Matthew Culyba, MD, PhD — Division of Infectious Diseases Assistant Professor of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.