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3/5/2019 - Medical Grand Rounds: CaMKII is a Redox Sensor with Evolved Implications for Health and Disease





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Identify and discuss physiological and pathological aspects of oxidation.
  • Explain how oxidation can trap CaMKII into a constitutively active confirmation
  • Recognize the impact of evolution on the physiological and pathological balance of oxidant signaling
  • Discuss reasons why antioxidant therapies have not been successful, clinically

Suggested Additional Reading:

Anderson JMCC 2015

Sanders, Sci Transl Med 2013

Min Luo, JCI 2013

Mark E. Anderson, MD, PhD — William Osler Professor of Medicine Director, Department of Medicine Johns Hopkins University Department of Medicine Physician in Chief, Johns Hopkins Hospital Director of Medicine for Johns Hopkins Medicine
Dr. Anderson is a stockholder with Allosteros Therapeutics (Founder Stock)
Authors disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.