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INTRODUCTION

3/12/2019 - Medical Grand Rounds: Resident Research Presentations

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Recognize bacterial bioenergetics as an emerging target for antibiotics.
  • Discuss features associated with long-term survival in metastatic breast cancer.
  • Discuss the factors contributing to increased hospital readmissions in patients with diabetes.
  • Describe Cyb5R3's role in the vasculature.
  • Identify the role of ubiquitin in processing of misfolded proteins.

Presentation Topics
Title:  Chemical Inhibition of the E3 Ligase CHIP as a Strategy to Stabilize CFTR Mutants
Presenter:  Ryan Belecanech, MD

Title:  Ndh2 and Nitric Oxide Resistance in Staphylococcus aureus
Presenter:  Peter Finin, MD

Title:  Features Associated with Long-Term Survival in Metastatic Breast Cancer
Presenter:  Natalie Klar, MD

Title:  Deconstructing the Discharge Process for Patients with Diabetes
Presenter:  Neeti Patel, MD
Title:  Role of a High-Frequency Polymorphism of NADH-Cytochrome b5 Reductase in the Cardiovascular system
Presenter:  Georgios Triantafyllou, MD

Suggested Additional Reading:

Lancet 2009; 373, 1891-1904

Lancet 2016; 388: 2519-31

Eur Respir J 2015; 46: 133-41

Nat Genet 2013; 45(10):1160-7

Nat Rev Dis Primers 2015; 1:15010.

Straub AC, Lohman AW, Billaud M, Johnstone SR, Dwyer ST et al. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 2012 Nov 15;491(7424):473-7

Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C et al. Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling. Circ Res. 2017 Jul 7;121(2):137-148

Lechauve C, Butcher JT, Freiwan A, Biwer LA, Keith JM et al. Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility. J Clin Invest. 2018 Nov 1;128(11):5073-5082. 

Authors:
Georgios Triantafyllou, MD — PGY3 Internal Medicine Resident, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Natalie Klar, MD — PGY3 Internal Medicine Resident, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Neeti Patel, MD — PGY3 Internal Medicine Resident, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Peter Finin, MD — PGY3 Internal Medicine Resident, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Ryan Belecanech, MD — PGY3 - Internal Medicine Resident, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Authors disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.