Step by Step






Credit Hours: CME 1.25

Target Audience:

This activity is directed to physicians who take care of hospitalized children, medical students, nurse practitioners, and physician assistants working in the emergency room, intensive care unit, or hospital wards.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Define three of the inflammatory arthritis - Rheumatic Fever, Reactive Arthritis and Juvenile Idiopathic Arthritis
  • Discuss the diagnostic criteria and treatment for each of the above arthritis.
  • Discuss the differences between Macrophage Activation Syndrome and Hemophagocytic Lymphohistiocytosis

There is no educational content to this course. This course is designed to only administer the post-test and collect CME evaluations for the podcast associated with this training.
A Note From Dr. Tarchichi:
This series was created to keep the busy physician of today informed and up to date on some of the most important diagnoses and issues we face every day in the care of hospitalized children. 

Suggested Additional Reading:

1.     John J, Chandran L. Arthritis in Children and Adolescents. Pediatrics in Review. Vol.32 No.11 November 2011

2.    Espinosa M, Gottlieb B. Juvenile Idiopathic Arthritis. Pediatrics in Review Vol.33 No.7 July 2012.

3.     Al-Samkari H, Berliner N. Annual Review of Pathology: Mechanism of Disease - Hemophagocytic Lymphohistiocytosis. Annu. Rev. Pathol. Mech. Dis. 2018.13:27-49.

4.     V. Boom, J. Anton, P. Lahdenne, P. Quartier, A. Ravelli5, N.M. Wulffraat, S.J. Vastert. Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Pediatric Rheumatology (2015) 13:55

5.     Aytac S, Deniz Batu E, Unal S, Bilinger Y, Cetin M, Tuncer M, Gumruk F, Ozen S. Macrophage activation syndrome in children with systemic juvenile idiopathic arthritis and systemic lupus erythematosus. Rheumatol Int (2016) 36:1421–1429

6.     Minoia F1, Davì S, Horne A, Demirkaya E, Bovis F, Li C, Lehmberg K, Weitzman S, Insalaco A, Wouters C, Shenoi S, Espada G, Ozen S, Anton J, Khubchandani R, Russo R, Pal P, Kasapcopur O, Miettunen P, Maritsi D, Merino R, Shakoory B, Alessio M, Chasnyk V, Sanner H, Gao YJ, Huasong Z, Kitoh T, Avcin T, Fischbach M, Frosch M, Grom A, Huber A, Jelusic M, Sawhney S, Uziel Y, Ruperto N, Martini A, Cron RQ, Ravelli A; Pediatric Rheumatology International Trials Organization; Childhood Arthritis and Rheumatology Research Alliance; Pediatric Rheumatology Collaborative Study Group; Histiocyte Society. Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: a multinational, multicenter study of 362 patients. Arthritis Rheumatol. 2014 Nov;66(11):3160-9. doi: 10.1002/art.38802.

Elaine Cassidy, MD — Associate Fellowship Program Director, Division of Pediatric Rheumatology Assistant Professor, Pediatrics, University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Tony R. Tarchichi MD — Assistant Professor, Department of Pediatrics, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center (UPMC.) Paul C . Gaffney Diagnostic Referral Group
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.