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ABIM MOC Activity ID

1/7/20 - Medical Grand Rounds: Bench to Bedside -Whole Genome Sequencing for Outbreak Detection: The Next Generation of Infection Prevention





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe a "traditional epidemiology" approach to identifying healthcare-associated infection clusters.
  • Recognize the advantages of whole genome sequencing over pulsed-field gel electrophoresis for determining genetic relatedness of bacteria.
  • Describe how whole genome sequencing surveillance is used to detect otherwise unidentified outbreaks.

Suggested Additional Reading:

  • Outbreak Investigations in Healthcare Settings. Centers for Disease Control and Prevention, accessible at, updated 6/29/2016.\
  • Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis. Clin Microbiol Rev 2017;30(4)1015-1063.
  • Sundermann AJ et al. Clin Infect Dis. 2019 Jul 16. pii: ciz666. doi: 10.1093/cid/ciz666

Graham Snyder, MD — Associate Professor of Medicine, Division of Infectious Diseases Medical Director, Infection Prevention University of Pittsburgh School of Medicine
Dr. Snyder is a Scientific Advisor; Infectious Diseases Connect.
Lee Harrison, MD — Professor of Medicine, Division of Infectious Diseases Associate Chief of Epidemiology and Education Head, Infectious Diseases Epidemiology Research Unit University of Pittsburgh School of Medicine
Dr. Harrison is a consultant with Pfizer, Sanofi Pasteur, Merck, GSK.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

The University of Pittsburgh is an affirmative action, equal opportunity institution.