Step by Step


ABIM MOC Activity ID

1/7/20 - Medical Grand Rounds: Bench to Bedside -Whole Genome Sequencing for Outbreak Detection: The Next Generation of Infection Prevention





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe a "traditional epidemiology" approach to identifying healthcare-associated infection clusters.
  • Recognize the advantages of whole genome sequencing over pulsed-field gel electrophoresis for determining genetic relatedness of bacteria.
  • Describe how whole genome sequencing surveillance is used to detect otherwise unidentified outbreaks.

Suggested Additional Reading:

  • Outbreak Investigations in Healthcare Settings. Centers for Disease Control and Prevention, accessible at, updated 6/29/2016.\
  • Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis. Clin Microbiol Rev 2017;30(4)1015-1063.
  • Sundermann AJ et al. Clin Infect Dis. 2019 Jul 16. pii: ciz666. doi: 10.1093/cid/ciz666

Graham Snyder, MD — Associate Professor of Medicine, Division of Infectious Diseases Medical Director, Infection Prevention University of Pittsburgh School of Medicine
Dr. Snyder is a Scientific Advisor; Infectious Diseases Connect.
Lee Harrison, MD — Professor of Medicine, Division of Infectious Diseases Associate Chief of Epidemiology and Education Head, Infectious Diseases Epidemiology Research Unit University of Pittsburgh School of Medicine
Dr. Harrison is a consultant with Pfizer, Sanofi Pasteur, Merck, GSK.
Authors disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.