Step by Step


ABIM MOC Activity ID

2/11/2020 - Medical Grand Rounds: Bench to Bedside





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Review how gut microbiota can contain glycosidases capable of cleavage of human blood group antigens as well as enzymes cleaving O-glycans from glycoproteins
  • Describe how improved enzymes for the removal of A/B blood type antigens, towards university (O) blood.
  • Describe the safety of red cell transfusion for patients undergoing cardiac surgery
  • Improve red cell transfusion practice
  • Describe the limitations of restrictive red cell transfusion in patients with acute coronary syndrome

Presentation Topics
Title:  Restrictive Red Cell Transfusion: Is it safe?
Presenter:  Darrell J. Triuli, MD

Title:  Discovery of CAZymes for cell surface glycan removal through metagenomics: towards universal blood
Presenter:  Stephen G. Withers, FRS

Suggested Additional Reading:

  • Carson JL, et al. American Heart Journal 2013. 165:964-71
  • Carson JL. et al. N Eng J Med. 2017. 377(13):1261-1272
  • Carson JL, et al. Am Heart J. 2018. 200:96-101
  • Mazer CD, et. al. N Eng J Med. 2017. 377(13):2133-2144
  • Chapanian, R., Kwan, D., Constantinescu, I. et al. Nat Commun 5, 4683 (2014).
  • Rahfeld, P., et al (2019) Nature Microbiology 4, 1475-1485.
  • Authors:
    Darrell Triulzi, MD — Professor of Pathology Director, Division of Transfusion Medicine University of Pittsburgh School of Medicine Medical Director, Clinical Services, Vitalant-Pittsburgh
    Dr. Triulzi receives grant/research support from Cerus Group, and he is a consultant with Fresenius Kabi.
    Stephen Withers, FRS — Professor of Chemistry and Biochemistry Department of Chemistry University of British Columbia
    No relationships with industry relevant to the content of this educational activity have been disclosed.
    No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

    The University of Pittsburgh is an affirmative action, equal opportunity institution.