University of Pittsburgh Health Sciences eLearning Environment Internet-based Studies in Education and Research
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INTRODUCTION
ABIM MOC Activity ID
2/11/2020 - Medical Grand Rounds: Bench to Bedside
QUIZ
EVALUATION
CERTIFICATE
INTRODUCTION
Credit Hours: CME 1.00
Target Audience:
Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.
Educational Objectives:
Presentation Topics
Upon completion of this activity, participants should be able to:
- Review how gut microbiota can contain glycosidases capable of cleavage of human blood group antigens as well as enzymes cleaving O-glycans from glycoproteins
- Describe how improved enzymes for the removal of A/B blood type antigens, towards university (O) blood.
- Describe the safety of red cell transfusion for patients undergoing cardiac surgery
- Improve red cell transfusion practice
- Describe the limitations of restrictive red cell transfusion in patients with acute coronary syndrome
Presentation Topics
Title: Restrictive Red Cell Transfusion: Is it safe?
Presenter: Darrell J. Triuli, MD
Title: Discovery of CAZymes for cell surface glycan removal through metagenomics: towards universal blood
Presenter: Stephen G. Withers, FRS
Suggested Additional Reading:
Carson JL, et al. American Heart Journal 2013. 165:964-71
Carson JL. et al. N Eng J Med. 2017. 377(13):1261-1272
Carson JL, et al. Am Heart J. 2018. 200:96-101
Mazer CD, et. al. N Eng J Med. 2017. 377(13):2133-2144
Chapanian, R., Kwan, D., Constantinescu, I. et al. Nat Commun 5, 4683 (2014).
Rahfeld, P., et al (2019) Nature Microbiology 4, 1475-1485.
Authors:
Darrell Triulzi, MD
—
Professor of Pathology
Director, Division of Transfusion Medicine
University of Pittsburgh School of Medicine
Medical Director, Clinical Services, Vitalant-Pittsburgh
Dr. Triulzi receives grant/research support from Cerus Group, and he is a consultant with Fresenius Kabi.
Dr. Triulzi receives grant/research support from Cerus Group, and he is a consultant with Fresenius Kabi.
Stephen Withers, FRS
—
Professor of Chemistry and Biochemistry
Department of Chemistry
University of British Columbia
No relationships with industry relevant to the content of this educational activity have been disclosed.
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters,
authors, content reviewers and/or anyone else in a position to
control the content of this education activity have relevant
financial relationships with any companies whose primary business
is producing, marketing, selling, re-selling, or distributing
healthcare products used by or on patients.
This activity is approved for AMA PRA Category 1 Creditâ„¢
The University of Pittsburgh is an affirmative action, equal opportunity institution.