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INTRODUCTION

ABIM MOC Activity ID

3/10/20 - Medical Grand Rounds: Lupus Research and Therapy: Emerging Perspectives

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe the roles of B cells in promoting lupus.
  • Recognize how innate immunity promotes lupus and what the relevant therapeutic targets are.
  • Identify potential pathogenic roles of T cells in lupus

Suggested Additional Reading:

  1. Shlomchik MJ. Activating systemic autoimmunity: B’s, T’s and Tolls. Curr Opin Immunol. 2009;21:626-633. PMCID: PMC2787881.
  2. Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ. Signals via the Adaptor MyD88 in B Cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in Lupus. Immunity. 2013;38:528-540. PMCID: PMC3638041.
  3. Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky M, Nickerson KM, and Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. J. Clin. Inv., 2020, in press.

Authors:
Amr H. Sawalha, MD — Professor and Chief, Division of Pediatric Rheumatology, Vincent Londino Endowed Chair in Pediatric Rheumatology, Director, Lupus Center of Excellence
University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
Mark Shlomchik, MD, PhD — UPMC Endowed and Distinguished Professor of Immunology, Chair, Department of Immunology,
University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Authors disclosure of relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients is listed above. No other planners, members of the planning committee, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits. Each physician should only claim credit commensurate with the extent of their participation in the activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.