University of Pittsburgh Health Sciences eLearning Environment Internet-based Studies in Education and Research
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INTRODUCTION
ABIM MOC Activity ID
3/10/20 - Medical Grand Rounds: Lupus Research and Therapy: Emerging Perspectives
QUIZ
EVALUATION
CERTIFICATE
INTRODUCTION
Credit Hours: CME 1.00
Target Audience:
Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.
Educational Objectives:
Upon completion of this activity, participants should be able to:
- Describe the roles of B cells in promoting lupus.
- Recognize how innate immunity promotes lupus and what the relevant therapeutic targets are.
- Identify potential pathogenic roles of T cells in lupus
Suggested Additional Reading:
- Shlomchik MJ. Activating systemic autoimmunity: B’s, T’s and Tolls. Curr Opin Immunol. 2009;21:626-633. PMCID: PMC2787881.
- Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ. Signals via the Adaptor MyD88 in B Cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in Lupus. Immunity. 2013;38:528-540. PMCID: PMC3638041.
- Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky M, Nickerson KM, and Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. J. Clin. Inv., 2020, in press.
Authors:
Amr H. Sawalha, MD
—
Professor and Chief, Division of Pediatric Rheumatology, Vincent Londino Endowed Chair in Pediatric Rheumatology, Director, Lupus Center of Excellence
University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
Mark Shlomchik, MD, PhD
—
UPMC Endowed and Distinguished Professor of Immunology,
Chair, Department of Immunology,
University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
University of Pittsburgh School of Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters,
authors, content reviewers and/or anyone else in a position to
control the content of this education activity have relevant
financial relationships with any companies whose primary business
is producing, marketing, selling, re-selling, or distributing
healthcare products used by or on patients.
This activity is approved for AMA PRA Category 1 Credit™
The University of Pittsburgh is an affirmative action, equal opportunity institution.