Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Topics Include:
Survival of the fattest? Association of BMI and Survival in Patients with Left Ventricular Systolic Dysfunction
Presented by: Tiffany Brazile, MD
Knowledge and Attitudes about Genetic Research in Black and White Women with Breast Cancer
Presented by: Sikemi Ibikunle, MD
Hypokalemia Induced Expression of WNK Bodies in Mouse and Human Tissue
Presented by: Sophia Knoell, MD
A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance
Presented by: Matthew Nguyen, MD
Molecular Correlates and Therapeutic Targets in T cell-inflamed verses non-T cell-inflamed Tumors Across Cancer Types
Presented by: Daniel Stapor, MD

Educational Objectives:

Upon completion of this activity, participants should be able to:

• Describe advances in immunotherapy have led to improvements in clinical response for many metastatic diseases.
• Acquire a basic understanding of the cellular mechanism of AMPK and the drug discovery process.
• Recognize a new mechanism of AMPK activation and its implications on cellular metabolism.
• Improve interpretation skills for standard molecular biology techniques.
• Describe potassium Homeostasis in distal convoluted tubule
• Explain the current state of minority recruitment in genomic research studies and potential impact
• Examine patient-identified barriers and genetic literacy as a barrier to conducting genomic research
• Review the attitudes of women with breast cancer towards genetic research
• Describe the effect of overweight and obesity on mortality and hospitalization in patients with left ventricular systolic dysfunction
• Explain the potential risks of weight loss in patients diagnosed with left ventricular systolic dysfunction
• Identify potential mechanisms for the protective effect of excess weight in patients diagnosed with left ventricular systolic dysfunction

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Suggested additional reading:

1. Carbone, S., Lavie, C. J., & Arena, R. (2017, February). Obesity and heart failure: focus on the obesity paradox. In Mayo Clinic Proceedings (Vol. 92, No. 2, pp. 266-279). Elsevier.
2. Padwal, R., et al. (2014). The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data. International journal of obesity, 38(8), 1110-1114.
3. Zhang, J., Begley, A., Jackson, R., Harrison, M., Pellicori, P., Clark, A. L., & Cleland, J. G. (2019). Body mass index and all-cause mortality in heart failure patients with normal and reduced ventricular ejection fraction: a dose–response meta-analysis. Clinical Research in Cardiology, 108(2), 119-132.
4. The Tuskegee Timeline. In: U.S. Public Health Service Syphilis Study at Tuskegee. Centers for Disease Control and Prevention, Atlanta, GA. n.d. https://www.cdc.gov/tuskegee/timeline.htm. Accessed Mar 12 2020.
5. Popejoy AB, Fullerton SM. Genomics is failing on diversity. Nature. 2016;538(7624):161–4.
6. Landry LG, Ali N, Williams DR, Rehm HL, Bonham VL. Lack of diversity in genomic databases is a barrier to translating precision medicine research into practice. Health Affairs (Project Hope). 2018;37(5):780–5.
7. Hardie, D.G., F.A. Ross, and S.A. Hawley, AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol, 2012. 13(4): p. 251-262.
8. Mihaylova, M.M. and R.J. Shaw, The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol, 2011. 13(9): p. 1016-1023.
9. Kim, J., et al., AMPK activators: mechanisms of action and physiological activities. Exp Mol Med, 2016. 48: p. e224.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.