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INTRODUCTION

ABIM MOC Activity ID

1/18/2022 - Medical Grand Rounds: Hypoxia-Inducible Factors in Physiology and Medicine

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe molecular mechanisms of O2 homeostasis
  • Explain the pathophysiology of ischemia-induced vascular remodeling
  • Explain the pathophysiology of hypoxia-induced pulmonary hypertension
  • Describe the genetics and pathophysiology of familial erythrocytosis


Abstract

Dr. Semenza is a professor of genetic medicine, pediatrics, radiation oncology, molecular radiation sciences, biological chemistry, medicine, and oncology at Johns Hopkins who was awarded the Nobel Prize in 2019 for his team's work on mechanisms of oxygen regulation. He has long been a leader in this field, specifically helping to elucidate genetic and cellular adaptations to hypoxia, including the discovery of hypoxia-inducible factor 1 (HIF-1). The discovery of this protein and its microbiologic role promises further understanding (and potential therapeutic targets) of widely pervasive diseases such as cardiovascular disease, anemia, diabetes, and cancer. We are excited to host him and hear about his scientific work with his lecture, "Hypoxia-Inducible Factors in Physiology and Medicine”.

Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements & Suggested Additional Reading:

Joint Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.


Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.


Suggested Additional Reading

Semenza GL. The genomics and genetics of oxygen homeostasis. Annu Rev Genomics Hum Genet 21:183-204 (2020). PMID: 32255719.

Semenza GL. Pharmacologic targeting of hypoxia-inducible factors. Annu Rev Pharmacol Toxicol 59:379-403 (2019). PMID: 30691683.

Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol 76:39-56 (2014). PMID: 23988176.

Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 9:47-71 (2014). PMID: 23937437. 

Authors:
Gregg L. Semenza, MD, PhD — Professor of Genetic Medicine
Professor of Biological Chemistry, Medicine, Oncology, Pediatrics, and Radiation Oncology and Molecular Radiation Sciences
Johns Hopkins School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

The University of Pittsburgh is an affirmative action, equal opportunity institution.