University of Pittsburgh Health Sciences eLearning Environment Internet-based Studies in Education and Research
INTRODUCTION
ABIM MOC Activity ID
1/18/2022 - Medical Grand Rounds: Hypoxia-Inducible Factors in Physiology and Medicine
QUIZ
EVALUATION
CERTIFICATE
Credit Hours: CME 1.00
Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.
Upon completion of this activity, participants should be able to:
- Describe molecular mechanisms of O2 homeostasis
- Explain the pathophysiology of ischemia-induced vascular remodeling
- Explain the pathophysiology of hypoxia-induced pulmonary hypertension
- Describe the genetics and pathophysiology of familial erythrocytosis
Abstract
Dr. Semenza is a professor of genetic medicine, pediatrics,
radiation oncology, molecular radiation sciences, biological chemistry,
medicine, and oncology at Johns Hopkins who was awarded the Nobel Prize in 2019
for his team's work on mechanisms of oxygen regulation. He has long been a
leader in this field, specifically helping to elucidate genetic and cellular
adaptations to hypoxia, including the discovery of hypoxia-inducible factor 1
(HIF-1). The discovery of this protein and its microbiologic role promises
further understanding (and potential therapeutic targets) of widely pervasive
diseases such as cardiovascular disease, anemia, diabetes, and cancer. We are excited to host him and hear about his scientific
work with his lecture, "Hypoxia-Inducible Factors in Physiology and
Medicine”.
Joint Accreditation Statement
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.
The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.
Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
Suggested Additional Reading
Semenza GL. The genomics and genetics of oxygen homeostasis. Annu Rev Genomics Hum Genet 21:183-204 (2020). PMID: 32255719.
Semenza GL. Pharmacologic targeting of hypoxia-inducible factors. Annu Rev Pharmacol Toxicol 59:379-403 (2019). PMID: 30691683.
Semenza GL. Hypoxia-inducible factor 1 and cardiovascular disease. Annu Rev Physiol 76:39-56 (2014). PMID: 23988176.
Semenza GL. Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology. Annu Rev Pathol 9:47-71 (2014). PMID: 23937437.
Professor of Biological Chemistry, Medicine, Oncology, Pediatrics, and Radiation Oncology and Molecular Radiation Sciences
Johns Hopkins School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
This activity is approved for AMA PRA Category 1 Credit™
The University of Pittsburgh is an affirmative action, equal opportunity institution.