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INTRODUCTION

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10/04/2022 - Medical Grand Rounds: Special K Club Series

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.
Presentations:
"Novel Role for MUC1 in Acid-Base Homeostasis”
Mohammad Al-Bataineh, DVM, MS, PhD
“Mapping the role of DNA damage and cellular senescence in aging”
Marc Gauthier, MD
“Von Willebrand Disease Aging and Bleeding Correlation Study (VWD ABC)”
Craig Seaman, MD, MS

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Provide mechanistic insights as to normal acid-base physiology.
  • Elucidate the possible contribution of MUC1 haploinsufficiency to metabolic acidosis in patients with ADTKD-MUC1
  • Demonstrate the importance of MUC1 in tumor progression.
  • Recognize the role of T1 inflammation in asthma
  • Describe how CCL5 (RANTES) may contribute to T1 inflammation in asthma
  • Recognize the importance of the overlap of T1 and T2 inflammation in asthma
  • Examine the role of von Willebrand factor in primary hemostasis.
  • Explain the effect of aging on von Willebrand factor levels in von Willebrand disease.
  • Describe the effect of aging on bleeding symptoms in von Willebrand disease.

Abstract
The Special K Club features our star scientists with K awards. We are very excited to welcome Drs. Mohammad Al-Bataineh, Marc Gauthier, and Craig Seaman for this installment of the Special K Club.

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Joint Accreditation Statement
In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.


Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.
Suggested Additional Reading

  1. Al-Bataineh, MM, TA Sutton, and RP Hughey, Novel roles for mucin 1 in the kidney. Curr Opin Nephrol Hypertens, 2017. 26(5): p. 384-91
  2. Finberg, KE, et al., The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A, 2005. 102(38): p. 13616-21
  3. Breton, S. and D Brown, Regulation of luminal acidification by the V-ATPase. Physiology (Bethesda), 2013. 28(5): p. 318-29
  4. Gauthier, M et al. Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias. JCI Insight 2 (2017)
  5. Gauthier, M et al. Dual role for CXCR3 and CCR5 in asthmatic type 1 inflammation. The Journal of allergy and clinical immunology 149, 113-124.e117 (2022)
  6. Modena, BD et al. Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. American journal of respiratory and critical care medicine 195, 1449-1463 (2017).
  7. Spiel AO et al. Von Willebrand factor in cardiovascular disease. Circulation. 2008;117:1449-59
  8. Favaloro EJ, Franchini M, Lippi Giuseppe. Aging hemostasis: Change to laboratory markers of hemostasis as we age - a narrative review. Semin Thromb Hemost. 2014;40:621-633
  9. Rydz N, Grabell J, Lillicrap D, James PD. Changes in von Willebrand factor level and von Willebrand activity with age in type 1 von Willebrand disease. Haemophilia. 2015;21:636-641
  10. Borhi M, Guglielmini G, Mezzasoma AM, et al. Increase of von Willebrand factor with aging in type 1 von Willebrand disease: fact or fiction? Haematologica. 2017;102:e431
  11. Sanders YV, Giezenaar MA, Laros-van Gorkom BA, et al. von Willebrand disease and aging: an evolving phenotype. J Thromb Haemost. 2014;12:1066-1075
  12. Flood VH, Christopherson PA, Cox-Gill J, et al. Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States. Blood. 2016;127:2481-2488
  13. Atiq F, Meijer K, Eikenboom J, et al. Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age-related increase of VWF in von Willebrand disease. Br J Haematol. 2018;182:93-105
  14. Swystun LL and Lillicrap. Genetic regulation of plasma von Willebrand factor levels in health and disease. J Thromb Haemost. 2018;16:2375-90
  15. De Wee EM, Sanders YV, Mauser-Bunschoten EP, et al. Determinants of bleeding phenotype in adult patients with moderate or severe von Willebrand disease. Thromb Haemost. 2012;108:683-692
  16. Seaman C and Ragni MV. The association of aging with von Willebrand factor levels and bleeding risk in type 1 von Willebrand disease. Clin Applied Thromb Hemost. 2018;24:434-438

Authors:
Craig Seaman, MD, MS — Assistant Professor of Medicine, Hematology/Oncology Division, University of Pittsburgh
Dr. Seaman discloses he is a consultant with Genentech, HEMA Biologics, Novo Nordisk, Sanofi, and Takeda.
Marc Gauthier, MD — Assistant Professor of Medicine, Pulmonary, Allergy and Critical Care Medicine Division, University of Pittsburgh
No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
Mohammad Al-Bataineh, DVM, MS, PhD — Assistant Professor of Medicine, Renal-Electrolyte Division, University of Pittsburgh
No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.