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10/25/2022 - Medical Grand Rounds: Mechanisms and Management of Atrial Fibrillation & Relaxin as a Therapy for Atrial Fibrillation





Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Abstract Guy Salama, PhD, and Sandeep Jain, MD, both Professors of Medicine in the Division of Cardiology, gave a fantastic Bench-to-Bedside presentation. Dr. Salama discussed his pre-clinical studies on the cardiovascular effects of Relaxin, an insulin-like hormone, and its role in the suppression of atrial fibrillation. Dr. Jain then offered his insight into the basic mechanisms of atrial fibrillation, as well as discuss rate versus rhythm control therapies.

Topic: “Mechanisms and Management of Atrial Fibrillation”
Presented by: Sandeep Jain, MD

Topic: “Relaxin as a Therapy for Atrial Fibrillation”
Presented by: Guy Salama, PhD

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe ways to diminish the prevalence of undiagnosed AF, incidence of AF-attributable stroke and unnecessary AF-attributable hospital encounters.
  • Identify and reach as many afflicted persons as possible
  • Employ ways to provide meaningful education to as to causes, consequences for AF
  • Examine treatment options for AF and all possible AF treatments options at major HVI sites.
  • List factors that promote AF. 
  • Describe what is Relaxin
  • Recognize RLX blocks AF induced by a premature pulse in aged rat hearts. Models of chronic hypertension (SHR) and HFpEF.
  • Explain how DRLX has genomic effects by activating Wnt1/β –catenin canonical signaling in myocytes and fibroblasts
  • Describe RNA-seq Analysis to identify the genomic effects of RLX

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Suggested Additional Reading

  • Perino A.C., et al. J Am Coll Cardiol. 2017;70(1):78-86.
  • Wazni et al, NEJM 2021
  • Andrade et al, NEJM, 2021
  • Jain SK, Novak PG, Sangrigoli R, et al. Heart Rhythm. 2020 Mar;17(3):485-491.
  • Lund, S. A., et al. (2009). J Cell Commun Signal 3(3-4): 311-322.
  • Chan, M. M., et al. (2016). Eur J Heart Fail 18(1): 81-88.
  • Anker, S. D. (2004). Heart 90(4): 464-470.
  • Braunwald, E. (2008).  NEJM 358: 2148-2159.
  • Henry et al., Heart Rhythm, 2016

    Joint Accreditation Statement:

    In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.

    Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Guy Salama, PhD — Professor of Medicine, Division of Cardiology, University of Pittsburgh School of Medicine, Heart and Vascular Institute, Vascular Medicine Institute
No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
Sandeep K. Jain, MD — Professor of Medicine, University of Pittsburgh School of Medicine
Director, Cardiac Electrophysiology, Director, UPMC Center for Atrial Fibrillation, UPMC Heart and Vascular Institute
Dr. Jain receives Grant / Research support from Medtronic, Boston Scientific. He is a clinical research trial PI for Medtronic, Boston Scientific, St. Jude.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

The University of Pittsburgh is an affirmative action, equal opportunity institution.