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INTRODUCTION

3/7/23 - Medical Grand Rounds: Special K Club Series- Post-GWAS Functional Genomics Analysis; Exploring Cardiac Diseases, and Machine Learning-driven Diagnosis and Management Strategy

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Evaluate the project on PAH functional genomics.
  • Outline the basic and translational studies on PAH pathogenesis.
  • Assess an example of career development as a physician-scientist, especially a transition from a trainee to PI.
  • Analyze the ongoing research in my lab which explores the journey from Animal Physiology to Stem Cell Functional Genomics
  • Explore the scientific society at U Pitt and UPMC, and the chances of collaborations
  • Describe how human stem cell platform will help the research of cardiovascular diseases
  • Describe Scalable Data/Model Sharing Platform for ML

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Suggested additional reading:

  • Rhodes, C. J., Batai, K., Bleda, M., Haimel, M., Southgate, L., Germain, M., Pauciulo, M. W., Hadinnapola, C., Aman, J., Girerd, B., Arora, A., Knight, J., Hanscombe, K. B., Karnes, J. H., Kaakinen, M Gall, H., Ulrich, A., Harbaum, L., Cebola, I., Ferrer, J., … US PAH Biobank Consortium (2019). Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. The Lancet. Respiratory medicine, 7(3), 227–238.
  • Jiang D, Sun W, Wu T, Zou M, Vasamsetti SB, Zhang X, Zhao Y, Tavakoli S, Dutta P, Florentin J, Chan SY, Wu D, Cui J, Finkel T, Li G. Post-GWAS functional analysis of the CDKN2A/B locus identifies CUX1 as a regulator of p16INK4a expression and cellular senescence. Nature Aging, 2022 Feb. https://doi.org/10.1038/s43587-022-00177-0.
  • Morrell, N. W., Aldred, M. A., Chung, W. K., Elliott, C. G., Nichols, W. C., Soubrier, F., Trembath, R. C., & Loyd, J. E. (2019). Genetics and genomics of pulmonary arterial hypertension. The European respiratory journal, 53(1), 1801899. https://doi.org/10.1183/13993003.01899-2018
  • https://doi.org/10.1093/eurheartj/ehz326
  • https://doi.org/10.3389/fgene.2020.00424 
    • https://doi.org/10.1124/pr.116.013003 Barndt et al. 2023. Biomolecules.Wu et al. 2019. European Heart J


    Joint Accreditation Statement

    In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit[s]™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This educational activity is approved for 1.0 contact hours.

    Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

    Authors:
    Haodi Wu, PhD — Assistant Professor of Medicine, Cardiology Division, University of Pittsburgh
    No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
    Joo Yoon, MD — Assistant Professor of Medicine, Pulmonary, Allergy and Critical Care Medicine Division, University of Pittsburgh
    No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
    Wei Sun, MD — Assistant Professor of Medicine, Cardiology Division, University of Pittsburgh
    No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
    No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

    This activity is approved for AMA PRA Category 1 Credit™

    The University of Pittsburgh is an affirmative action, equal opportunity institution.