Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

"It’s a two-way street”: lung-blood cross-talk during pathogen-mediated lung injury”
Presented by: William Bain, MD - Assistant Professor of Medicine, Pulmonary, Allergy, Critical Care, and Sleep Medicine

“Metabolites as biomarkers and mediators of host resilience in acute lung injury”
Presented by: Tomeka Suber, MD, PhD - Assistant Professor of Medicine, Pulmonary, Allergy, Critical Care, and Sleep Medicine

"Inhibition of Virally-Induced TFEB Proteasomal Degradation as a Host-Centric Therapeutic Approach for Coronaviral Infection"
Presented by: Travis Lear, PhD - Post-Doctoral Fellow, Aging Institute

Educational Objectives:

Upon completion of this activity, participants should be able to:

Improve diagnostic skills to recognize ARDS subphenotypes based on clinical and inflammatory biomarkers
Implement strategies to apply precision medicine to treating ARDS subphenotypes
Appreciate the role of lysosomal Activity on anti-viral host defense
Recognize the potential in modulating protein degradation to affect biology
Envisage the use of in vivo models of coronaviral infection to test hypotheses
Improve identification of biological risk factors for hyperemesis gravidum
Increase clinical recognition of air-blood barrier disruption during pneumonia and lung injury
Improve clinical prognostication by increased recognition of platelet deficiency as a risk factor for ARDS

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Suggested Additional Reading:

Suber, T.L., Wendell, S.G., Mullett, S.J. et al. Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome. Respir Res 24, 136 (2023).
Calfee CS, Delucchi K, Parsons PE, Thompson BT, et al.; NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Md. 2014 Aug;2(8):611-20. doi: 10.1016/S2213-2600(14)70097-9. Epub 2014 May 19. PMCID: PMC4154544.
Kitsios GD, Yang L, Manatakis DV, et al. Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome. Crit Care Med. 2019 Dec;47(12):1724-1734. PMCID: PMC6865808.
Choi, Y., Bowman, J. W. & Jung, J. U. Autophagy during viral infection — a double-edged sword. Nature Reviews Microbiology 16, 341-354, doi:10.1038/s41579-018-0003-6 (2018).
Settembre, C. et al. TFEB links autophagy to lysosomal biogenesis. Science 332, 1429-1433, doi:10.1126/science.1204592 (2011).
Ghosh, S. et al. β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway. Cell 183, 1520-1535.e1514 (2020).
Fezjo M, et al. GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature. 2024 Jan;625(7996):760-767. Epub 2023 Dec 13.
Shah FA, et al. Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury. Am J Respir Cell Mol Biol. 2024 Feb 1.
Wei Y, et al. A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. Am J Respir Crit Care Med. 2017 May 15;195(10):1353-1361. doi: 10.1164/rccm.201605-0946OC.
Bain W, et al. Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury. Blood Adv. 2019 Feb 12;3(3):432-445.
Mills, E., Ryan, D., Prag, H. et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature 556, 113–117 (2018).

Joint Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician (CME)

The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Authors:

Tomeka Suber, MD, PhD — Assistant Professor of Medicine, Pulmonary, Allergy, Critical Care, and Sleep Medicine, UPMC
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

Travis Lear, PhD — Post-Doctoral Fellow, Aging Institute, UPMC
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

William Bain, MD — Assistant Professor of Medicine, Pulmonary, Allergy, Critical Care, and Sleep Medicine, UPMC
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.

No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.