Step by Step

INTRODUCTION

ABIM MOC Activity ID

10/8/2024 - Medical Grand Rounds: Special K Research Conference

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Faculty, residents, fellows, and community physicians in General Internal Medicine and subspecialties.

"Store-Operated Calcium Entry Channels: A Key Driver in Colorectal Cancer Progression"
Trayambak Pathak, PhD // Postdoctoral Associate, Vascular Medicine Institute

"Base-pair Resolution Transcription Factor Action in Systemic Sclerosis-associated Interstitial Lung Disease"
Eleanor Valenzi, MD // Assistant Professor of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine

"Targeting Red Cell Metabolism and Erythropoiesis: New Therapeutic Strategies in Sickle Cell Disease"
Julia Xu, MD, MScGH // Assistant Professor of Medicine, Division of Classical Hematology

Educational Objectives:

Upon completion of this activity, participants should be able to:

    • Identify and classify pathogenic cell types in systemic sclerosis
    • Describe the application of single-cell sequencing tools available to study the epigenome
    • Investigate the mechanisms  of transcription factor dysregulation in pulmonary fibrosis. 
    • Describe the consequences of chronic anemia in sickle cell disease. 
    • Identify existing treatment options for anemia in sickle cell disease.
    • Describe novel therapeutic approaches in sickle cell disease.
    • Identify the role of calcium channels in colorectal cancer progression
    • Identify the role of mitrochondrial metabolism in colorectal cancer progression
    • Develop store-operated calcium entry channels as a novel target to control colorectal cancer progression

Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Suggested Additional Reading:

  • Valenzi, E. et al. Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease. Ann Rheum Dis (2019). https://doi.org:10.1136/annrheumdis-2018-214865 
  • Stuart, T., Srivastava, A., Madad, S., et al. Single-cell chromatin state analysis with Signac. Nat Methods 18, 1333-1341 (2021). https://doi.org:10.1038/s41592-021-01282-5 
  • Brennan, K. J. et al. Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation. Dev Cell 58, 1898-1916 e1899 (2023). https://doi.org:10.1016/j.devcel.2023.07.007
  • Xu JZ, Thein SL. Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches. Blood. 2022 May 19;139(20):3030-3039. doi: 10.1182/blood.2021013873. PMID: 35587865; PMCID: PMC9121844.
  • Ataga KI, Gordeuk VR, Agodoa I, et al. Low hemoglobin increases risk for cerebrovascular disease, kidney disease, pulmonary vasculopathy, and mortality in sickle cell disease: A systematic literature review and meta-analysis. PLoS One. 2020 Apr 3;15(4):e0229959. doi: 10.1371/journal.pone.0229959.
  • Xu JZ, Vercellotti GM. Pyruvate kinase activators: targeting red cell metabolism in sickle cell disease. Hematology Am Soc Hematol Educ Program. 2023 Dec 8;2023(1):107-113. doi: 10.1182/hematology.2023000467.
  • https://pubmed.ncbi.nlm.nih.gov/26400989/
  • https://www.nature.com/articles/cr2017155
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358640/


Joint Accreditation Statement

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician (CME)

The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credits™.Each physician should only claim credit commensurate with the extent of their participation in the activity.


Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Authors:
Eleanor Valenzi, MD — Assistant Professor of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Julia Xu, MD, MScGH — Assistant Professor of Medicine, Division of Classical Hematology, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Trayambak Pathak, PhD — Postdoctoral Associate, Vascular Medicine Institute, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.