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INTRODUCTION

5/1/25 Anesthesiology Journal Club - TAK-925 (Danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid induced Respiratory Depression and Sedation without Affecting Analgesia in Healthy Men

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: CME 1.00

Target Audience:

Anesthesiologists and anesthesiologists-in-training and other anesthesia professionals, nurse anesthetists and anesthesia assistants.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Describe opioid-induced, post-operative respiratory depression.
  • Explain orexin’s role in wakefulness and danavorexton as an orexin receptor agonist. 
  • Evaluate the safety and efficacy of danavorexton in opioid-induce respiratory depression.

Suggested Additional Reading & Joint Accreditation Statement - Note: This Accreditation Statement Supersedes All Other Statements:

Joint Accreditation Statement:

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


The University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Each physician should only claim credit commensurate with the extent of their participation in the activity. 


Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

Suggested Additional Reading

  1.  van Lemmen, M, et al. (2025) TAK-925 (Danavorexton), an Orexin Receptor 2 Agonist, Reduces Opioid-induced Respiratory Depression and Sedation without Affecting Analgesia in Healthy Men. Anesthesiology. 142 (4): 628-38
  2. Khelemsky, Y, et al (2015) Incidence and demographics of post-operative nalaxone administration: a 13-year experience at a major tertiary teaching institution. Pain Physician. 18 (5): E827-9
  3. Suzuki, M, et al. (2024) Effects of the orexin receptor 2 agonist danavorexton on emergence from general anesthesia and opioid-induced sedation, respiratory depression, and analgesia in rates and monkeys. Br J Anaesth. 132(3):541-52

Authors:
Andrea Gomez Sanchez, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclosed.
Marc Peretti, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
Stephen McHugh, MD, FASA — Assistant Professor, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Sylvie Bertrand, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

This activity is approved for AMA PRA Category 1 Credit™

The University of Pittsburgh is an affirmative action, equal opportunity institution.