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2/5/26 Anesthesiology Journal Club - Esmolol as an Adjunct in Multimodal Anesthesia: A Systematic Review and Meta-Analysis of Its Opioid-Sparing and Analgesic Effects

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INTRODUCTION

Credit Hours: 0.75

Target Audience:

Anesthesiologists and anesthesiologists-in-training and other anesthesia professionals, nurse anesthetists and anesthesia assistants.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Recall that a meta-analysis is used to synthesize multiple studies, thereby increasing power and external validity. 
  • Examine the existing literature surrounding how beta blockers could potentially reduce pain.
  • Interrogate the risks and benefits of adding an esmolol infusion to your multimodal analgesic regimen. 

Suggested Additional Reading:

1. Davidson EM, Doursout MF, Szmuk P, Chelly JE. Antinociceptive and cardiovascular properties of esmolol following formalin injection in rats. Can J Anaesth. 2001 Jan;48(1):59-64. doi: 10.1007/BF03019816. PMID: 11212051.

2. Gelineau AM, King MR, Ladha KS, Burns SM, Houle T, Anderson TA. Intraoperative Esmolol as an Adjunct for Perioperative Opioid and Postoperative Pain Reduction: A Systematic Review, Meta-analysis, and Meta-regression. Anesth Analg. 2018;126:1035–1049

3. Mariano ER, Dickerson DM, Szokol JW, et al. A multisociety organizational consensus process to define guiding principles for acute perioperative pain management. Reg Anesth Pain Med. 2022;47:118–127

Authors:
Daniel Kim, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Joshua Mills, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
Stephen McHugh, MD, FASA — Assistant Professor, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Yu Chen, MBBS — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 0.75 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.