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INTRODUCTION

Professional Profile Details

3/19/2026 Anesthesiology Grand Rounds -Liposomal Bupivacaine: The Good, The Bad, The Ugly - Steve Orebaugh, MD.

QUIZ

EVALUATION

CERTIFICATE

INTRODUCTION

Credit Hours: 1.00

Target Audience:

Anesthesiologists and anesthesiologists-in-training and other anesthesia professionals, nurse anesthetists and anesthesia assistants.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Explain the pharmacologic properties and mechanisms of action of liposomal bupivacaine (LB).
  • Summarize the early basic science evidence supporting the use of liposomal bupivacaine.
  • Critically appraise clinical studies that both support and do not support the use of liposomal bupivacaine.
  • Identify the key requirements necessary to achieve effective neural blockade.
  • Analyze potential factors contributing to failed efficacy of liposomal bupivacaine.

Suggested Additional Reading:

  • Smoot JD  Aesthetic Surg J 2012;32:69
  • Bramlett K  Knee 2012 doi:10.1016/j.knee.2011.12.004
  • Verdecchia NM  J Shoulder Elbow Surg 2020;30:986
  • Amundson AW  Anesthesiology 2017;126:1139
  • Schroer WC  J Arthroplasty 2015;30 (Suppl 1):64
  • Hyland SJ   J Arthroplasty 2019;34:488
  • Ilfeld BM Anesthesiology 2021;134:283
  • Abdallah FW RAPM 2021;46:291
  • Dinges H-C 2021;46:490
  • Hussain N  Anesthesiology 2021;134:147
  • Hussain N   RAPM 2021;46:61
  • Chan TCW Anesthesiology 2024;141:732

Authors:
Steve Orebaugh, MD — Professor, Anesthesiology and Perioperative Medicine
Director, Outpatient Orthopedic Anesthesiology, UPMC Montefiore
Co-Chair, Residency Curriculum Committee
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.