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9/4/26 - Anesthesiology Journal Club -Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial

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Introduction

Credit Hours: 1.00

Target Audience:

Anesthesiologists and anesthesiologists-in-training and other anesthesia professionals, nurse anesthetists and anesthesia assistants.

Educational Objectives:

Upon completion of this activity, participants should be able to:

  • Critically appraise research literature evaluating neuromuscular blockade reversal strategies and their impact on postoperative pulmonary outcomes.
  • Apply evidence-based decision-making when selecting and managing neuromuscular blockade reversal agents during the perioperative period.
  • Integrate clinical trial data on neuromuscular blockade reversal into perioperative practice to reduce postoperative pulmonary complications and improve patient outcomes.

Suggested Additional Reading:

  • Kirmeier E, Eriksson L, Lewald H et al.Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study. The Lancet Respiratory Medicine, 2018; 7, 129-140>
  • Kheterpal S, Vaughn MT, Dubovoy TZ, Shah NJ, Bash LD, Colquhoun DA, Shanks AM, Mathis MR, Soto RG, Bardia A, Bartels K, McCormick PJ, Schonberger RB, Saager L. Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER): A Multicenter Matched Cohort Analysis. Anesthesiology. 2020 Jun;132(6):1371-1381.
  • Thilen SR, Hansen BE, Ramaiah R, Kent CD, Treggiari MM, Bhananker SM. Intraoperative neuromuscular monitoring site and residual paralysis. Anesthesiology. 2012 Nov;117(5):964-72. 

Authors:
Ethan Crispell, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
Haani Jafri, MD, PhD — PGY-2 Resident (PANTHER Research Program), PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
Stephen McHugh, MD, FASA — Assistant Professor, Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine
No members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
Tsuyoshi Nemoto, MD — PGY-2 Resident, UPMC Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh
No relationships with industry relevant to the content of this educational activity have been disclosed.
No other members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships with any companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

The University of Pittsburgh School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Each physician should only claim credit commensurate with the extent of their participation in the activity.

Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity.

The University of Pittsburgh is an affirmative action, equal opportunity institution.